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Instructor Rolf A. Prade, Room 409
LSE, Tel: 4 7522. Hours Mondays and Wednesdays from 1:00 PM to
3:00 PM
Course Description In depth discussion of lessons learned
from simple eukaryotes such as S. cerevisiae (yeast),
A. nidulans (fungus), D. melanogaster (fly) and
C. elegans (worm).
Prerequisites A solid understanding of basic cellular
maintenance and propagation processes illustrated by introductory
courses such as, Micro 2124, Biol 3024, 3014, Plp 3344 or Bioch
3653, plus one or more specific courses such as Gene 5102, Clmol
4273, 4123, Bioch 5753, 5853, 6763, Ento 5043, 5003, Plp 3553,
5104, 5724, 6102, 6202 or Bot 5813
Text No specific textbook is required. Introductory
Textbooks in Genetics, Biochemistry, Cell and Molecular Biology
should be extensively used to update background information.
This course is based on the discussion of current issues in genetics,
thus, articles and other materials should be copied from subscriptions
available at the Edmon Low Library (http://www.library.okstate.edu).
Rules and Policies OSU rules and policies will be strictly
enforced, specially regarding academic dishonesty/misconduct,
special accommodations for students, retention & grading
policies, class attendance and add & drop dates
Scoring
Evaluations of oral presentations
during the course. Oral presentation evaluations will be based
on completeness of content and adherence to normally accepted
meeting and conference guidelines.
A written review paper on any
topic of molecular genetics following the guidelines of any publication
by the American Society for Microbiology. Two original copies
of the final manuscript should be submitted no later than the
first day of Finals.
There will be 100 possible
points, 50 for the Review Article and 50 for the Oral Presentations.
Grading 100-90, A; 89-80, B;
79-70, C; 69-60, D and below 60, F.
Objectives and Format The goal of this course is to offer
in-depth discussion opportunities of current issues in genetics
through analysis of seminal research conducted with simple model
eukaryotes (yeasts, fungi, flies, worms and plants). Selections
of topics are based on the state-of-the-art research papers represented
by one or more model organisms (e.g., mating and yeast). Selected
research papers are presented in a seminar format (see preliminary
outline). Each presentation includes a 15-minute presentation
and a 15-minute discussion period. Four to five research papers
are expected to be discussed per week.
Preliminary Outline
Week Theme/Activity
01 Introduction
02 Background Genetics from the Bacterial World I
03 Background Genetics from the Bacterial World II
04 Viruses - HIV
05 Mating and Related Cellular Decisions
06 Genetics of the Cell Cycle
07 Asexual Development
08 Break (October 12 13)
09 Fundamentals of Biological Clocks
10 Carbon and Nitrogen Catabolite Repression
11 Genetics of Body Plan Formation
12 Homeobox Genes: Structure, Function and Evolution
13 Cell-Cell Interactions and Cell Fate Specification
14 Genetics of Flowering
15 Pre-Finals
16 Finals
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