Genetics of Simple Eukaryotes - MICR 6304

Syllabus
F 2003
Prade 1998 - Offered every other year in the Spring

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Instructor Rolf A. Prade, Room 409 LSE, Tel: 4 7522. Hours Mondays and Wednesdays from 1:00 PM to 3:00 PM

Course Description In depth discussion of lessons learned from simple eukaryotes such as S. cerevisiae (yeast), A. nidulans (fungus), D. melanogaster (fly) and C. elegans (worm).

Prerequisites A solid understanding of basic cellular maintenance and propagation processes illustrated by introductory courses such as, Micro 2124, Biol 3024, 3014, Plp 3344 or Bioch 3653, plus one or more specific courses such as Gene 5102, Clmol 4273, 4123, Bioch 5753, 5853, 6763, Ento 5043, 5003, Plp 3553, 5104, 5724, 6102, 6202 or Bot 5813

Text No specific textbook is required. Introductory Textbooks in Genetics, Biochemistry, Cell and Molecular Biology should be extensively used to update background information. This course is based on the discussion of current issues in genetics, thus, articles and other materials should be copied from subscriptions available at the Edmon Low Library (http://www.library.okstate.edu).

Rules and Policies OSU rules and policies will be strictly enforced, specially regarding academic dishonesty/misconduct, special accommodations for students, retention & grading policies, class attendance and add & drop dates

Scoring

Evaluations of oral presentations during the course. Oral presentation evaluations will be based on completeness of content and adherence to normally accepted meeting and conference guidelines.

A written review paper on any topic of molecular genetics following the guidelines of any publication by the American Society for Microbiology. Two original copies of the final manuscript should be submitted no later than the first day of Finals.

There will be 100 possible points, 50 for the Review Article and 50 for the Oral Presentations.

Grading 100-90, A; 89-80, B; 79-70, C; 69-60, D and below 60, F.

Objectives and Format The goal of this course is to offer in-depth discussion opportunities of current issues in genetics through analysis of seminal research conducted with simple model eukaryotes (yeasts, fungi, flies, worms and plants). Selections of topics are based on the state-of-the-art research papers represented by one or more model organisms (e.g., mating and yeast). Selected research papers are presented in a seminar format (see preliminary outline). Each presentation includes a 15-minute presentation and a 15-minute discussion period. Four to five research papers are expected to be discussed per week.

Preliminary Outline

Week Theme/Activity
01 Introduction
02 Background Genetics from the Bacterial World I
03 Background Genetics from the Bacterial World II
04 Viruses - HIV
05 Mating and Related Cellular Decisions
06 Genetics of the Cell Cycle
07 Asexual Development
08 Break (October 12 ­13)
09 Fundamentals of Biological Clocks
10 Carbon and Nitrogen Catabolite Repression
11 Genetics of Body Plan Formation
12 Homeobox Genes: Structure, Function and Evolution
13 Cell-Cell Interactions and Cell Fate Specification
14 Genetics of Flowering
15 Pre-Finals
16 Finals