Doctor of Philosophv. Immunology, 1984 University of Texas, Southwestern Medical Center, Dallas, TX . Master of Science. Microbiology, 1979 Brighm Young Univ., Provo, UT. Bachelor of Science. Microbiology, 1976. Brigham Young Univ., Provo, UT.
1993 to present. Associate Professor ot Microbiology, Oklahoma State University. 1991 to present. Co-director of the Hybridoma Center for the Agricultural and Biological Sciences, Oklahoma State Univ. 1988 to 1993. Assistant Professor of Microbiology, Oklahoma State University. 1984 to 1988. Post-Doctoral Fellow. The University ot Utah Medical Center.
The migration of Langerhans cells in mammalian skin: The skin represents a major site of interaction between higher organisms and their external environment. Therefore, it is not surprising that mammalian skin contains all of the components necessary for the destruction and removal of bacteria, viruses and cancerous tissue. Collectively, these components have been termed skin associated Iymphoid tissue (SALT). Specialized cells within the skin, termed Langerhans cells, carry foreign substances to lymph nodes below the skin in order to stimulate immune responses which will ultimately remove these substances. We have shown that ultraviolet radiation and certain bacterial toxins cause Langerhans cells to migrate when applied to the skin of mice. We am currently using these agents to determinine what molecular signals are involved in regulating the migration of Langerhans cells during responses to foreign substances. Current results suggest that soluble proteins released from Langerhans cells and other cell types within the skin may be involved.
Burnham DK, Lackey A, Manering M, Jaensson E, Pearson J, Tyler .O., Melson D and L.G. Talent. 2003. Effects of 17a-ethinylestradiol on immune parameters in the lizard Sceloporus occidentalis. Environ Toxicol 18:211-218.
Rhee, YS, Hermann, JR, Burnham, K, Aruitt, AB and BJ Stoecker. 2002. The effects of chromium and copper supplementation on mitogen-stimulated T cell proliferation in hypercholesterolemic postmenopausal women. Clin Exp Immunol 127:463-469.
Henri S, Vremec D, Kamath A, Waithman J, Williams S, Benoist C, Burnham K, Saeland S, Handman E, and K Shortman. 2001. The dendritic cell populations of mouse lymph nodes, J Immunol 167:741-748.
Burnham, K, Robb, L, Scott, C, Okeeffe, M and K Shortman.
2000. Effect of granulocyte/macrophage colony stimulating factor
on the generation of epidermal Langerhans cells, J Interferon
Cytokine Res 20:1071.